生物醫藥技術全國重點實驗室
（香港大學）
State Key Laboratory of Pharmaceutical Biotechnology
（The University of Hong Kong)
Field of Research
Metabolic regulation of diabetic and cardiovascular diseases
Biography
As a consequence of overnutrition and sedentary lifestyle, the increasing prevalence of obesity and its related complications has become a global public health concern. Dr. Geng’s research focuses on the metabolic regulation of diabetic and cardiovascular diseases from molecular study to clinical investigation, contributing to the identification of new biomarkers and development of novel therapeutic strategies. Especially, He is interested in the role and functioning mechanisms of metabolic hormones, such as FGF21 and insulin.
Publications
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Wan J*, LL Geng*#, Fu Y, Zhang Q, Guan G, Jiang X, Xu A, Jin P#. Clinical, genetic, and proteomic characteristics of type 2 diabetes complicated with exogenous insulin antibody syndrome: a case-control study. *Co-first author. #Co-corresponding author. Diabetes Research and Clinical Practice, 2025 Jul;225:112262.
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LL Geng#, XY Yi, Y Lin, XYD Abulimiti, LG Jin, JS Yu, AM Xu#. Site-specific analysis and functional characterization of N-linked glycosylation for β-Klotho protein. #Co-corresponding author. Int J Biol Macromol, 2025 Feb, 289:138846.
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LG Jin*, LL Geng*, L Ying, LL Shu, K Ye, RY Yang, Y Liu, Y Wang, Y Cai, X Jiang, Q Wang, XQ Yan, BY Liao, J Liu, FY Duan, G Sweeney, CWH Woo, Y Wang, ZY Xia, QZ Lian, and AM Xu. The FGF21-Sirtuin 3 axis confers the protective effects of exercise against diabetic cardiomyopathy by governing mitochondrial integrity. *Co-first author. Circulation, 2022 Nov, 146 (20):1537-1557.
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LL Geng, BY Liao, LG Jin, JS Yu, XY Zhao, YT Zhao, L Zhong, BL Wang, JF Li, J Liu, JK Yang, W Jia, QZ Lian, and AM Xu. β-Klotho promotes glycolysis and glucose-stimulated insulin secretion via GP130. Nature Metabolism, 2022 May, 4 (5): 608-626.
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LL Geng , Wong CL, Liao B, Lin Y, Han H, Lam KSL, Xu A, Lee CH, Tam VHK. Development of a novel diagnostic assay for insulin receptor autoantibodies based on a patient with autoimmune hypoglycaemia. Front Endocrinol. 2022 Oct 25;13:1029297.
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LL Geng, Diao X, Han H, Lin Y, Liang W, Xu A. Type 1 diabetes complicated with cyclic vomiting syndrome and exogenous insulin antibody syndrome: A case report. Front Endocrinol. 2022 Nov 10;13:1043301.
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BY Liao*, LL Geng*, F Zhang, L Wei, PKK Yeung, LL Shu, KSL Lam, SK Chung, JL Chang, AM Xu, K Wang, and RLC Hoo. Adipocyte fatty acid-binding protein exacerbates cerebral ischemia injury by disrupting the blood-brain barrier. *Co-first author. European Heart Journal, 2020 Sep, 41 (33): 3169-3180.
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LL Geng, KSL Lam, and AM Xu. The therapeutic potential of FGF21 in metabolic disease: from bench to clinic. Nature Reviews Endocrinology, 2020 Aug, 16 (11): 654-667.
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LL Geng, BY Liao, LG Jin, Z Huang, CR Triggle, H Ding, JL Zhang, Y Huang, ZF Lin, and AM Xu. Exercise alleviates obesity-induced metabolic dysfunction via enhancing FGF21 sensitivity in adipose tissues. Cell Reports, 2019 Mar, 26 (10): 2738-2752.
Awards
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October 2018, Keystone Symposia Scholarship;
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August 2021, Faculty Outstanding Research Output Award;
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March 2024, Faculty Outstanding Research Output Award;
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September 2025, Best Oral Presentation Award of ICDM.