Dr. Chao LUAN

Post-doctoral Fellow

PhD

Biography

Dr. Luan is an Associate Chief Physician in the Department of Dermatology at the Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS-PUMC). Concurrently, she serves as a Visiting Scholar at the State Key Laboratory of Pharmaceutical Biotechnology (SKLPB), the University of Hong Kong. Her primary research centres on the pathogenesis of psoriasis, photo-aging, and photo-dermatology. During her tenure at the SKLPB, she is leading a project focused on developing an ultrasensitive proximity-based immunoassay. This assay aims to advance the detection and understanding of dermatology-related autoimmune diseases, including Lupus, Dermatomyositis, Scleroderma, and Psoriasis.

Publications

Hu Y, Zhang L, Chen H, Huang S, Shu M, Shao N, Ding E, Wang L, Luan C, Zhang J, Chen K. Personalized ultraviolet A1 phototherapy strategies for steroid-refractory hand-foot eczema: A prospective study. J Am Acad Dermatol. 2025;93(3):820-821. doi:10.1016/j.jaad.2025.05.1381(Co-corresponding author)
Zuo Z, He S, Qiu Y, Guo R, He Y, Jiao C, Xia Y, Liu W, Luan C, Guo W. Salvianolic acid A prevents UV-induced skin damage by inhibiting the cGAS-STING pathway. Int Immunopharmacol. 2024 May 10;132:111971. doi: 10.1016/j.intimp.2024.111971. Epub 2024 Apr 1. PMID: 38565040. (Co-corresponding author)
Xuyue Zhou; Yu Hu; Lingxi Liu; Lihao Liu; Hongying Chen; Dan Huang; Mei Ju; Chao Luan;Kun Chen; Jiaan Zhang ; IL-33-mediated activation of mast cells is involved in the progression of imiquimod-induced psoriasis-like dermatitis, Cell Communication and Signaling, 2023,21(1) (Co-corresponding author)
Luan C, He Y, Liu W, Rong Y, Gao J, Xu K, Yu H, Hu Y, Zhang J, Chen K, Guo W. PCSK9 inhibition interrupts the cross-talk between keratinocytes and macrophages and prevents UVB-induced skin damage. J Biol Chem. 2023 Jul;299(7):104895. (First author)
Chao Luan; Yu Hu; Mei Ju; Dan Huang; Rong‐Lin Zhang; Xiao‐Hua Zhang; Pan‐Pan Tian; YanZhu; Chen Zhuang; Jia‐An Zhang; Kun Chen ; Treatment of vitiligo with 308‐nm light emitting diode: Our experience from a two‐year follow‐up of Chinese patients, Photodermatology, Photoimmunology & Photomedicine, 2022, 38(5): 489-494 (Co-first author)
Chao Luan; Xundi Chen; Yun Zhu; Jared M. Osland; Skyler D. Gerber; Melissa Dodds; Yu Hu;Min Chen; Rong Yuan ; Potentiation of Psoriasis-Like Inflammation by PCSK9, Journal of Investigative Dermatology, 2019, 139(4): 859-867( First author)
Jinyu Wang, Xundi Chen, Jared Osland, Skyler J Gerber, Chao Luan, Kristin Delfino, Leslie Goodwin, Rong Yuan, Deletion of Nrip1 Extends Female Mice Longevity, Increases Autophagy, and Delays Cell Senescence, The Journals of Gerontology: Series A, Volume 73, Issue 7, July 2018, Pages 882–892, https://doi.org/10.1093/gerona/glx257
Luan C, Chen X, Hu Y, Hao Z, Osland JM, Chen X, Gerber SD, Chen M, Gu H, Yuan R. Overexpression and potential roles of NRIP1 in psoriasis. Oncotarget. 2016 Nov 8;7(45):74236-74246. doi: 10.18632/oncotarget.12371. PMID: 27708240; PMCID: PMC5342049. (First author)

Grants

1. Study of the mechanism of silencing PCSK9 promoting apoptosis and suppressing NF-κB pathway in UVB-induced keratinocytes via inhibiting REG3A-EXTL3-PI3K-AKT pathway. (2020.01-2022.12) National Natural Science Foundation

2. PCSK9 through REG3A -EXTL3 PI3K - AKT regulate keratinocyte apoptosis and the mechanism of the nf-kappa B pathway. (2019.7-2022.6). Science and Technology Department of Jiangsu province, the basic research plan.