Field of Research

1. Development of HPLC–MS/MS‑based analytical methods for untargeted and targeted metabolomics and metabolic flux analysis;

2. Discovery and mechanistic investigation of serum metabolic biomarkers in obesity and obesity‑associated diabetes;

3. Elucidation of the roles and mechanisms of metabolites and metabolic enzymes in brown adipose tissue thermogenesis;

Biography

Dr. Ru Yi obtained his PhD from the State Key Laboratory of Environmental and Biological Analysis at Hong Kong Baptist University, where he focused on the development and application of mass spectrometry‑based analytical methods in metabolomics. He has established a series of novel methods for the qualitative and quantitative analysis of small‑molecule metabolites, including sulfur‑containing metabolites, carbohydrate metabolites, and acylglycines, and has developed metabolic flux analysis methods for arginine metabolism and gluconeogenesis. In 2025, Dr. Ru joined the State Key Laboratory of Pharmaceutical Biotechnology at The University of Hong Kong. His current research focuses on elucidating the roles and mechanisms of metabolites and metabolic enzymes in the development of obesity and obesity‑associated diabetes, as well as uncovering new functions and regulatory mechanisms of metabolites in thermogenic adipose tissues.

Publications

1. Ru Y, Xiang L, Shen Q, et al. Metabolomics and Lipidomics Study Reveals Metabolic Dysregulation in Epididymal Adipose Tissue of db/db Mice. Health and Metabolism, 2025, 2(3): 1;

2. Ru Y, Xiang L, Shi J, et al. Derivatization of N-Acyl Glycines by 3-Nitrophenylhydrazine for Targeted Metabolomics Analysis and Their Application to the Study of Diabetes Progression in Mice. Analytical Chemistry, 2023, 95(4): 2183-2191; 

3. Ru Y, Liu K, Kong X, et al. Synthesis of selenylated polysaccharides from Momordica charantia L. and its hypoglycemic activity in streptozotocin-induced diabetic mice. International journal of biological macromolecules, 2020, 152: 295-304; 

4. Ru Y, Chen X, Wang J, et al, Structural Characterization, Hypoglycemic Effects and Mechanism of a Novel Polysaccharide from Tetrastigma Hemsleyanum Diels et Gilg, International Journal of Biological Macromolecules, 15 February 2019, Vol. 123, P. 775-783; 

5. Ru Y, Chen X, Wang J, et al, Polysaccharides from Tetrastigma Hemsleyanum Diels et Gilg: Extraction Optimization, Structural Characterizations, Antioxidant and Antihyperlipidemic Activities in Hyperlipidemic Mice, International Journal of Biological Macromolecules, 15 March 2019, Vol. 125, P. 1033-1041;

6. Ru Y, Chen X, Xu J, et al, Hypoglycemic Effects of a Polysaccharide from Tetrastigma hemsleyanum Diels & Gilg in Alloxan-Induced Diabetic Mice, Chemistry & Biodiversity, 28 May 2018, Issue 8, Vol. 15, e1800070;

Academic Conference:

• The 3rd Annual Meeting of the Metabolomics Branch of the Chinese Biophysical Society and the 2023 International Symposium on Metabolomics (27/10/2023-29/10/2023)                                                        

• 17th International Symposium on Persistent Toxic Substances & Health (18/09/2023-22/09/2023)                     

• Chinese Chemical Society 2016 China Polysaccharide Conference (20/10/2016-22/10/2016)