生物醫藥技術全國重點實驗室
（香港大學）
State Key Laboratory of Pharmaceutical Biotechnology
（The University of Hong Kong)
Field of Research
Metabolic syndrome
Biography
Dr. Shen is currently a Post-doctoral Fellow in the Department of Medicine at the University of Hong Kong. She received her PhD from Tongji Medical College, Huazhong University of Science and Technology (HUST). Her research focuses on therapeutic strategies and the molecular mechanisms underlying obesity-related metabolic complications. This includes investigating the interplay between cerebrovascular dysfunction and neuroinflammation, the mechanisms of novel multi-receptor agonists and the regulatory roles of novel biomarkers in MASH progression.
Publications
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Shen Q, Chen Z, …, Zhang G*. Reversal of prolonged obesity-associated cerebrovascular dysfunction by inhibiting microglial Tak1. Nature Neuroscience. 2020; 23: 832-841. (IF: 24.884)
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Shen Q, Zhang G*. Depletion of microglia mitigates cerebrovascular dysfunction in diet-induced obesity mice. AJP-Endocrinology and Metabolism. (IF: 3.1)
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Chui ZSW#, Shen Q#, Xu A*. Current status and future perspectives of FGF21 analogues in clinical trials. Trends Endocrinol Metab. 2024 May;35(5):371-384. (IF: 12.6)
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Zhou RH#, Yue M#, Shen Q#, …, Chen ZW*. Glucagon-like peptide-1 receptor agonist prevents pulmonary post-acute sequelae of COVID-19 associated with type 2 diabetes. Advanced Science. Under review, manu ID:2684808. (IF: 14.3)
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Wu LF#, Meng J#, Shen Q, …, Zhang G*. Caffeine inhibits hypothalamic A1R to excite oxytocin neuron and ameliorate dietary obesity in mice. Nature Communications. 2017; 8: 15904. (IF: 12.353)
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Zhang Y, Guan Y, Pan S, Yan L, Wang P, Chen Z, Shen Q, Zhao F, Zhang X, Li J, Cai D, Zhang G. Hypothalamic extended synaptotagmin-3 contributes to the development of dietary obesity and related metabolic disorders. PNAS. 2020; 117: 20149-20158. (IF: 11.205)
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Zhao F, Zhang T, Shen Q, ..., Zhang G*. Tak1 in the astrocytes of mediobasal hypothalamus regulates anxiety-like behavior in mice. Glia. 2021; 69: 609-618. (IF: 8.073)
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Yin K, Zhang T, Lu X, Shen Q, …, Zhang G*. Tak1 licenses mitochondrial transfer from astrocytes to POMC neurons to maintain glucose and cholesterol homeostasis. Cell Rep. 2024 Dec 24;43(12):114983. (IF: 6.9)
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Ru Y#, Xiang L#, Shen Q, Su X, Xu A*, Cai Z*. Metabolomics and Lipidomics Study Reveals Metabolic Dysregulation in Epididymal Adipose Tissue of db/db Mice. Health and Metabolism. 2025, 2 (3), 1.
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National Natural Science Foundation of China, Youth Fund, No. 82201449, Mechanism of microglial mitochondrial Drp1 in alleviating cerebrovascular dysfunction. 300,000 RMB. Principal Investigator. 2023.01.01-2025.12.31.
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National Natural Science Foundation of China, General Program Fund, No. 82570990. Mechanistic study of FGF21/leptin dual receptor agonists in the treatment of obesity-related metabolic diseases. 480,000 RMB. Principal Investigator. 2026.01.01-2029.12.31.
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Shenzhen Medical Research Fund (SMRF), Youth Program. No. A250301, Mechanistic Study of Soluble CDCP1 in Treating Metabolic Dysfunction-Associated Fatty Liver Disease. 800,000 RMB. Principal Investigator. 2026.01.01-2028.12.31.
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General Program Sponsored by Shenzhen Natural Science Foundation in Basic Research Fund. No. 2025041, Mechanism Study of TAK1-Mediated Aging-Related Cerebrovascular Dysfunction in Microglia. 300,000 RMB. Principal Investigator. 2026.01.01-2028.12.31.