Dr. Wu Xiaoping, Amber
吳曉萍

Wu, X., Zhang, Z., Li, J., Zong, J., Yuan, L., Shu, L., ... & Hoo, R. L. (2025). Chchd10: A Novel Metabolic Sensor Modulating Adipose Tissue Homeostasis. Advanced Science. (IF: 14.1) * This paper provides pioneering evidence that disruption of the p62-Chchd10 axis is a critical event impairing the adaptive capacity of adipose tissue.

Wu, X., Cheong, L. Y., Yuan, L., Jin, L., Zhang, Z., Xiao, Y., ... & Shu, L. (2024). Islet‐Resident Memory T Cells Orchestrate the Immunopathogenesis of Type 1 Diabetes through the FABP4‐CXCL10 Axis. Advanced Science. (IF: 15.1) * This paper presents the first mechanistic evidence that TRM cells contribute to pancreatic islet destruction.

Wu, X., Shu, L., Zhang, Z., Li, J., Zong, J., Cheong, L.Y., Ye, D., Lam, K.S., Song, E., Wang, C. Xu, A., and Hoo, R. L. (2021). Adipocyte fatty acid binding protein promotes the onset and progression of liver fibrosis via mediating the crosstalk between liver sinusoidal endothelial cells and hepatic stellate cells. Advanced Science. (IF: 17.52)

Zong J*., Wu X*., Huang X., Yuan L., Yuan K., Zhang Z., Jiang M., Ping Z., Cheong LY., Xu A., Hoo R. (2025) Adipocyte-derived shed Syndecan-4 suppresses lipolysis via FGF2-FGFR1 axis leading to impaired adipose tissue browning and adaptive thermogenesis. Molecular Metabolism. (IF: 7.0)

Cheng, Y.*, Wu, X*., Nie, X., Wu, Y., Zhang, C., Lee, S. M. Y., ... & Li, J. (2022). Natural compound glycyrrhetinic acid protects against doxorubicin-induced cardiotoxicity by activating the Nrf2/HO-1 signaling pathway. Phytomedicine. (IF: 6.66)

Liu, Z.*, Wu, X*., Dai, K., Li, R., Zhang, J., Sheng, D., Lee, S.M.Y., Leung, G.P.H., Zhou, G.C. and Li, J. (2022). The new andrographolide derivative AGS-30 induces apoptosis in human colon cancer cells by activating a ROS-dependent JNK signaling pathway. Phytomedicine. (IF: 6.66)

Li, H. L.*, Wu, X*., Xu, A., and Hoo, R. L. C. (2021). A-FABP in metabolic diseases and the therapeutic implications: an update. International journal of molecular sciences. (IF: 5.92)

Shu, L., Hoo, R.L., Wu, X., Pan, Y., Lee, I.P., Cheong, L.Y., Bornstein, S.R., Rong, X., Guo, J., and Xu, A. (2017). A-FABP mediates adaptive thermogenesis by promoting intracellular activation of thyroid hormones in brown adipocytes. Nature Communications. (IF: 14.92)

Cheong, L.Y., Wang, B., Wang, Q., Jin, L., Kwok, K.H., Wu, X., Shu, L., Lin, H., Chung, S.K., Cheng, K.K. and Hoo, R.L., (2023). Fibroblastic reticular cells in lymph nodes potentiate white adipose tissue being through neuro-immune crosstalk in male mice. Nature Communications. (IF: 17.694)

Yang, K., Velagapudi, S., Akhmedov, A., Kraler, S., Lapikova-Bryhinska, T., Schmiady, M. O., Wu, X., ... & Lüscher, T. F. (2023). Chronic SIRT1 supplementation in diabetic mice improves endothelial function by suppressing oxidative stress. Cardiovascular Research. (IF: 14.239)

Zhang, P., Liu, D., Wu, L., Wu, X., Yan, K., Fan, M., Zou, D., Song, E., Jiang, Y., Xu, Y. and Wu, X. ... & Ye, D., (2025). Neutrophil serine proteases NE and PR3 controlled by the miR-223/STAT3 axis potentiate MASH and liver fibrosis. Hepatology. (IF: 13)

Xiao, Y., Shu, L., Wu, X., Liu, Y., Cheong, L.Y., Liao, B., Xiao, X., Hoo, R.L., Zhou, Z., and Xu, A. (2021). Fatty acid binding protein 4 promotes autoimmune diabetes by recruitment and activation of pancreatic islet macrophages. JCI insight. (IF: 9.48)

Li, J., Li, R., Wu, X., Hoo, R.L.C., Lee, S.M.Y., Cheung, T.M.Y., Ho, B.S.Y., and Leung, G.P.H. (2021). Amauroderma rugosum Protects PC12 Cells against 6-OHDA-Induced Neurotoxicity through Antioxidant and Antiapoptotic Effects. Oxidative Medicine and Cellular Longevity. (IF: 7.31)

Shu, L., Zhong, L., Xiao, Y., Wu, X., Liu, Y., Jiang, X., Tang, T., Hoo, R., Zhou, Z., and Xu, A. (2020). Neutrophil elastase triggers the development of autoimmune diabetes by exacerbating innate immune responses in pancreatic islets of non-obese diabetic mice. Clinical Science. (IF: 5.22)