Dr. YUAN Lufengzi
袁盧鳳子

Field of Research

Adipose tissue biology, immunology, obesity, energy metabolism, osteoporosis, bone metabolism

Biography

Dr. Yuan obtained her Bachelor's degree in Clinical Pharmacy from Anhui Medical University and subsequently completed her Ph.D. degree from The University of Hong Kong. She is currently a postdoctoral fellow in the Department of Pharmacology and Pharmacy, HKU. Her research focuses on elucidating the critical cross-talk whereby immune cells regulate metabolic homeostasis in adipose and skeletal tissues.

Publications

1. Wu X, Cheong LY, Yuan L, Jin L, Zhang Z, Xiao Y, Zhou Z, Xu A, *Hoo RL, *Shu L. Islet-Resident Memory T Cells Orchestrate the Immunopathogenesis of Type 1 Diabetes through the FABP4-CXCL10 Axis. Advanced Science 2024 Aug; doi: 10.1002/advs.202308461.

2. Wu, X., Zhang, Z., Li, J., Zong, J., Yuan, L., Shu, L., Cheong, L. Y., Huang, X., Jiang, M., Ping, Z., Xu, A., & Hoo, R. L. C. Chchd10: A Novel Metabolic Sensor Modulating Adipose Tissue Homeostasis. Advanced science 2025; doi: 10.1002/advs.202408763 

3. Zong J, Wu X, Huang X, Yuan L, Yuan K, Zhang Z, Jiang M, Ping Z, Cheong LY, Xu A, *Hoo RL. Adipocyte-derived shed Syndecan-4 suppresses lipolysis contributing to impaired adipose tissue browning and adaptive thermogenesis. Molecular Metabolism 2025; doi: 10.1016/j.molmet.2025.102133

Awards and conferences:

2025.4 Oral Presentation Award, Third Place

Hong Kong Inter-University Postdoctoral Symposium in Biomedical Science, HK                     

The roles of neutrophil and neutrophil derived serine proteases in white adipose browning and adaptive thermogenesis.  

2025.8 Poster Presentation

12th Aging research and Drug Discovery Meeting (ARDD), Denmark

The roles of neutrophils and neutrophil elastase in the regulation of postmenopausal osteoporosis.